Compositions and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis, and abnormal cell proliferation

US7053200B1 · kind B1 · utility

Assignee

• Baylor College of Medicine · US

Inventors

• Huda Y. Zoghbi · Houston, US
• Hugo Bellen · Houston, US
• Nessan Bermingham · London, GB
• Bassem Hassan · Houston, US
• Nissim Ben-arie · Mevaseret Tsiyon, IL

Key dates

• Filing date: Jun 1, 2000
• Grant date: May 30, 2006
• Expiry date: Oct 27, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions and methods are disclosed for the therapeutic use of an atonal-associated nucleic acid or amino acid sequence. Also, an animal heterozygous for an atonal-associated gene inactivation is also disclosed having at least one atonal-associated nucleic acid sequence replaced by insertion of a heterologous nucleic acid sequence used to detect expression driven by an atonal-associated promoter sequence, wherein the inactivation of the atonal-associated nucleic acid sequence prevents expression of the atonal-associated gene.