Process for regioselective demethylation of p-methoxy group in phenolic ester and diaryl ketone moieties
US7053218B2 · kind B2 · utility
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Key dates
| Filing date | Sep 8, 2004 |
| Grant date | May 30, 2006 |
| Priority date | — |
| Expiry date | Sep 29, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C67/31
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Demethylation of 3′, 4′-dimethoxy or 3′, 4′, 5′-trimethoxy benzoic ester of a phenol is carried out in the presence of an excess of aluminum halide in an organic solvent to get 4′-Hydroxy, 3′-methoxy or 4′ hydroxy, 3′, 5′-dimethoxy benzoic acid ester of a phenol. The reaction is also applicable to 3′, 4′, 5′-trimethoxy diaryl ketone and some natural products like reserpine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.