Process for the production of 4-(17α-alkoxymethyl-17β-substituted 3-oxoestra-4,9-dien-11β-yl) benzaldehyde-(1E)-oxime derivatives

US7053229B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Gerd Schubert · Jena, DE
• Sven Ring · Jena, DE

Key dates

• Filing date: Nov 9, 2001
• Grant date: May 30, 2006
• Expiry date: Jul 13, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J41/0083
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to a process for the production of 4-(17α-alkoxymethyl-17β-substituted-3-oxoestra-4,9-dien-11β-yl)benzaldehyde-(1E)-oxime derivatives of general formula (I)in which R means an amino group, an O—C1-7-alkyl- or O-aryl radical, an S—C1-7-alkyl- or S-aryl radical, an NH—C1-7-alkyl- or NH-aryl radical or an N-di-C1-7-alkyl radical, and R1 means a hydrogen atom or a C1-6-alkyl radical, which yields the target compounds of formula (I) with high yield and selectivity.