Differentiation of non-insulin producing cells into insulin producing cells by GLP-1 or exendin-4 and uses thereof

US7056734B1 · kind B1 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services, N.I.H. · US

Inventors

• Josephine Egan · Baltimore, US
• Riccardo Perfetti · Los Angeles, US
• Antonino Passaniti · White Hall, US
• Nigel H. Greig · Phoenix, US
• Harold W. Holloway · Middle River, US
• Joel E. Habener · Newton, US
• Doris Stoffers · Brookline, US

Key dates

• Filing date: Aug 10, 1999
• Grant date: Jun 6, 2006
• Expiry date: Aug 10, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2501/335
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a population of insulin producing cells made by a process comprising contacting non-insulin producing cells with a growth factor selected from the group consisting of GLP-1 or Exendin-4, growth factors having amino acid sequences substantially homologous to GLP-1 or Exendin-4, and fragmets thereof. The present invention also relates to methods of differentiating non-insulin producing cells into insulin producing cells and of enriching a population of cells for insulin-producing cells. The present invention also relates to methods of treating diabetes.