Reduced FK228 and use thereof
US7056884B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 9, 2001 |
| Grant date | Jun 6, 2006 |
| Priority date | — |
| Expiry date | Mar 27, 2022 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to reduced FK228 of the formula (I)wherein R1 and R2 are the same or different and each is a hydrogen atom or a thiol-protecting group, or a salt thereof, and a histone deacetylase inhibitor containing this compound, an expression potentiator and a reactivation promoter of a transgene, and pharmaceutical agents containing them as active ingredients. The reduced FK228 or a salt thereof has a strong histone deacetylase inhibitory activity and this compound can be used for the prophylaxis or treatment of various diseases, in which histone deacetylation is involved, and for the gene therapy of such diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.