PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules

US7057012B1 · kind B1 · utility

Assignee

• The General Hospital Corporation · US

Inventors

• Thomas J. Gardella · Needham, US
• Henry M. Kronenberg · Belmont, US
• John T. Potts, Jr. · Newton, US
• Harald Juppner · Cambridge, US

Key dates

• Filing date: Dec 30, 1999
• Grant date: Jun 6, 2006
• Expiry date: Dec 30, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel parathyroid hormone (PTH) peptides and analogs thereof of the PTH(1–34) fragment are disclosed that combine the N-terminal signaling domain (residues 1–9) and the C-terminal binding domain (residues 15–31) via a linker. Nucleic acid molecules and peptides for PTH(1–9)-(Gly)5-PTH(15–31) (PG5) and (1–9)-(Gly)7-PTH(15–31) and a novel PTH receptor are disclosed. Additionally, methods of screening for PTH agonists, pharmaceutical compositions and methods of treatment are disclosed.