Decellularized vascular prostheses resistant to thrombus occlusion and immunological rejection
US7060022B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 6, 2003 |
| Grant date | Jun 13, 2006 |
| Priority date | — |
| Expiry date | Jan 17, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/414
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present invention relates to decellularized vascular prostheses that are resistant to thrombus occlusion and have a low level of immunogenicity. The vascular prostheses are denuded of cells, and coated with an anti-thrombogenic agent and a growth factor that promotes recellularization and further reduces the immunogenicity. The prostheses have high mechanical strength, resist aneurysm rupture, and allow for secure surgical sutures while maintaining structural integrity. The present invention provides vascular prostheses that are blood vessels, valves or portions of vessels containing valves. The present invention is also useful for coating synthetic vascular stents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.