Modular targeted liposomal delivery system

US7060291B1 · kind B1 · utility

Assignee

• Transpave Inc. · CA

Inventors

• Paul R. Meers · Princeton Junction, US
• Tong Shangguan · Princeton, US
• Donna Cabral-Lilly · Princeton, US
• Patrick L. Ahl · West Point, US
• Ravi K. Erukulla · Plainsboro, US
• Andrew S. Janoff · Yardley, US

Key dates

• Filing date: Nov 17, 2000
• Grant date: Jun 13, 2006
• Expiry date: Feb 3, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/1271
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A liposome including a fusogenic liposome, a linking moiety and a targeting moiety. The fusogenic liposome is a lipid bilayer encapsulating contents. The linking moiety is electrostatically bound to the lipid bilayer, and the targeting moiety is covalently bound to the linking moiety. The liposome may also include a stabilizing moiety interposed between the linking and targeting moieties, and covalently bound to both. Alternatively, the stabilizing and targeting moieties may be covalently bound to separate linking moieties, the linking moieties being electrostatically bound to the lipid bilayer.