Isoquinoline derivatives

US7060707B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Matthias Wiesner · Seeheim-Jugenheim, DE
• Simon Goodman
• Horst Kessler · Schwalbach, DE
• Georgette Thumshirn · Birkenfeld, DE
• Dirk Weber · Basel, CH
• Dirk Gottschling · Mittelbiberach, DE

Key dates

• Filing date: Feb 7, 2003
• Grant date: Jun 13, 2006
• Expiry date: Feb 7, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Isoquinoline derivatives of the general formula (I) in which X, Y, Z, R1, R2 and n are as defined in Patent Claim (1), and physiologically acceptable salts or solvates thereof, are integrin inhibitors and can be employed for combating thromboses, cardiac infarction, coronary heart diseases, arteriosclerosis, inflammation, tumors, osteoporosis, infections and restenosis after angioplasty or in pathological processes which are maintained or propagated by angiogenesis.