Presentation of hydrophobic antigens to T-cells by CD1 molecules

US7063844B2 · kind B2 · utility

Assignee

• The Brigham and Women's Hospital, Inc. · US

Inventors

• Steven A. Porcelli · The Bronx, US
• Michael B. Brenner · Ashland, US
• Evan Beckman · Newton, US
• Stephen T. Furlong · Wilmington, US

Key dates

• Filing date: May 21, 2001
• Grant date: Jun 20, 2006
• Expiry date: May 21, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P19/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are CD-1 presented antigens, compositions, cells, inhibitors and methods relating to the use of hydrophobic antigen presentation by CD1 molecules, including: methods for detecting the presence of a CD1-presented hydrophobic antigen in a sample; methods for isolating such CD1-presented antigens and isolated antigens; vaccines containing CD1-presented antigens and vaccination methods; methods of blocking CD1 antigen presentation; methods of identifying and/or isolating CD1 blocking agents and the isolated CD1 blocking agents; methods of inducing CD1 expression; and T-cells for use in the methods disclosed herein.