Patent · US Expired

Hybrid LT-A/CT-B holotoxin for use as an adjuvant

US7063852B2 · kind B2 · utility

2Cited by
3References
2Claims
0Family size

Assignee

Inventor

Key dates

Filing dateMay 21, 2001
Grant dateJun 20, 2006
Priority date—
Expiry dateApr 19, 2022

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY02A50/30
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The present invention provides a novel composition which is a hybrid heat labile enterotoxin comprising the A-subunit of the heat labile toxin of Escherichia coli (LT-A) and the B-subunit of the cholera enterotoxin of Vibrio cholerae (CT-B). The hybrid toxin is designated LT-A/CT-B. The LT-A subunit, the CT-B subunit, or both subunits of the hybrid toxin may be mutant subunits, e.g., differing from wild-type subunits by amino acid substitutions, deletions or additions. Also provided are methods of using the novel LT-A/CT-B comprising compositions of the invention as adjuvants for vaccines, methods of making the LT-A/CT-B hybrid holotoxin, and kits.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.