Yeast-based process for production of l-pac
US7063969B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Dec 13, 2000 |
| Grant date | Jun 20, 2006 |
| Priority date | — |
| Expiry date | Mar 18, 2021 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/54
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides a method of synthesis of a substituted or unsubstituted carbinol compound, comprising the steps of subjecting the corresponding substituted or unsubstituted aromatic aldehyde to acyloin condensation mediated by yeast in the presence of either (a) a supereritical fluid or (b) a liquefied gas, and recovering the carbinol compound. Preferably the yeast is Saccharomyces cerevisiae. In a particularly preferred embodiment the aromatic aldehyde is benzaldehyde and the carbinol is phenylacetylcarbinol, according to the reaction (I): in which the benzaldehyde, the pyruvic acid, or both may optionally be substituted.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.