Process for the synthesis of 1,3,4,5-tetrahydro-2H-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
US7064200B2 · kind B2 · utility
2Cited by
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11Claims
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Key dates
| Filing date | Feb 17, 2005 |
| Grant date | Jun 20, 2006 |
| Priority date | — |
| Expiry date | Feb 17, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Process for the synthesis of compounds of formula (I):wherein R1 and R2, which may be the same or different, each represent a linear or branched (C1–C8)alkoxy group or form, together with the carbon atom carrying them, a 1,3-dioxane, 1,3-dioxolane or 1,3-dioxepane ring.Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid, and hydrates thereof.
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