Transgenic mammals having human Ig loci including plural VH and VK regions and antibodies produced therefrom
US7064244B2 · kind B2 · utility
107Cited by
4References
6Claims
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Key dates
| Filing date | Feb 19, 2002 |
| Grant date | Jun 20, 2006 |
| Priority date | — |
| Expiry date | Dec 31, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/206
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VH and Vκ) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.