Methods for identifying compounds for regulating muscle mass or function using dopamine receptors
US7067113B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 18, 2002 |
| Grant date | Jun 27, 2006 |
| Priority date | — |
| Expiry date | Jan 3, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2885
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Screening methods for identifying compounds that bind to or activate (D1 or D5 dopamine receptors individually or in combination) or potentially regulate skeletal muscle mass or function in vivo. Also disclosed are screening methods for identifying compounds that prolong or augment the activation of D1 or D5 dopamine receptors or of D1 or D5 dopamine receptor signal transduction pathways and increase D1 or D5 dopamine receptor expression. Pharmaceutical compositions comprising D1 or D5 dopamine receptor agonists, antibodies to D1 or D5 dopamine receptors and methods for increasing skeletal muscle mass or function or for the treatment of skeletal muscle atrophy using D1 or D5 dopamine receptors as the target for intervention and methods for treatment of muscular dystrophies are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.