Methods of using mutant flt3-ligand polypeptides to induce cellular expansion
US7067118B2 · kind B2 · utility
3Cited by
3References
54Claims
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Key dates
| Filing date | Jul 16, 2001 |
| Grant date | Jun 27, 2006 |
| Priority date | — |
| Expiry date | Jul 16, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A screening method for identifying mutant polypeptides having at least one amino acid difference from a wild type protein involved in a receptor-ligand interaction is disclosed. Also disclosed are mutant polypeptides of the hematopoietic growth factor flt3-Ligand (flt3-L) identified using this method, nucleic acids encoding these flt3-L mutant polypeptides, and methods of treatment involving in vitro and in vivo use of the mutant polypeptides and nucleic acids.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.