Human papillomavirus multiplexed assay
US7067258B2 · kind B2 · utility
6Cited by
1References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 25, 2003 |
| Grant date | Jun 27, 2006 |
| Priority date | — |
| Expiry date | Apr 25, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/025
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to an immunoassay for simultaneously measuring the presence of antibodies to a plurality of HPV types that utilizes particle-based flow cytometric analysis. The presence and/or titre of neutralizing antibodies in a test sample are determined in a competitive format, where known, type-specific, fluorescently labeled neutralizing monoclonal antibodies compete with antibodies within a test sample for binding to conformationally sensitive, neutralizing epitopes on specific HPV-VLPs. The invention also provides a microsphere complex comprising a microsphere coupled to an HPV VLP.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.