Synthetic receptors, libraries and uses thereof

US7067326B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• W. Clark Still · New York, US
• Ge Li · Tangxia, CN
• Helma Wennemers · Bruchköbel, DE

Key dates

• Filing date: Jan 13, 1995
• Grant date: Jun 27, 2006
• Expiry date: Mar 30, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B70/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Libraries of synthetic receptors are disclosed. The receptors include a polyfunctional organic template which is covalently linked to two or more oligomers. The oligomers may be the same or different and may be straight chain, cyclic or branched. The template may be linked to an identifier which is unique to each synthetic receptor. Although the identifier may be directly attached to the template, it is more common and preferable that the template be covalently linked to a solid support which is itself linked to the identifier. Methods of preparing synthetic receptors and libraries of synthetic receptors are also disclosed as are methods for assaying the libraries to determine which receptors have various desirable characteristics. Among the desirable characteristics are (a) the ability to bind an acceptor molecule; (b) biological activity; (c) the ability to catalyze or inhibit a reaction and (d) potential utility for separating compounds in chromatography.