Antimitotic eleuthesides
US7067494B2 · kind B2 · utility
2Cited by
12References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 25, 2002 |
| Grant date | Jun 27, 2006 |
| Priority date | — |
| Expiry date | Feb 24, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H17/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention provides analogs of eleutherobin and the eleuthesides modified at the C-11 position or comprising an epoxide functionality from C-11 to C-12. C-11 to C-12 is an ideal location for conjugating functional moieties to the eleutherobin pharmacophore without significant loss of antimitotic activity. Moieties that may be conjugated at C-11 include those intended to increase the solubility of the pharmacophore, to facilitate drug formulation, or to facilitate in vivo delivery or targeting.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.