7,8,9,10-tetrahydro-6H-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2H-pyrrolo[2,1-b]-quinazolinone derivatives

US7067519B2 · kind B2 · utility

Inventors

• Hamed Aissaoui · Allschwil, CH
• Martine Clozel · Binningen, CH
• Walter Fischli · Allschwil, CH
• Ralf Koberstein · Bad Kötzting, DE
• Thierry Sifferlen · Allschwil, CH
• Thomas Weller · Binningen, CH

Key dates

• Filing date: Jul 8, 2003
• Grant date: Jun 27, 2006
• Expiry date: Jul 8, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel 7,8,9,10-tetrahydro-6H-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2H-pyrrolo[2,1-b]-quinazolinone derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.