VP22 proteins and uses thereof
US7067632B2 · kind B2 · utility
10Cited by
9References
5Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jul 10, 2003 |
| Grant date | Jun 27, 2006 |
| Priority date | — |
| Expiry date | Jul 10, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/16622
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Herpesviral VP22 proteins (and variants) are used to modify cell structure and cell division, by their newly found property of binding to microtubules in cells. Uses of VP22 to exploit this property include stabilisation of animal cellular microtubules in vivo and in vitro, e.g. to retard or arrest cell division or induce cell death. The microtubule binding function of VP22 can be exploited by reagent use in vitro to study microtubules or the cell cycle particularly at cell division, and pharmaceutically to retard or arrest cell division of cells such as neoplastic cells or protozoal parasite cells in vitro or in vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.