Isolated SH3 genes associates with myeloproliferative disorders and leukemia and uses thereof
US7070954B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Apr 16, 1999 |
| Grant date | Jul 4, 2006 |
| Priority date | — |
| Expiry date | Apr 16, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/47
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human gene (SH3D1A), some polymorphic alleles of which cause susceptibility to cancers hematopoietic disorders and in particular platelet disorders, Down Syndrome, megakaryocytic disorders and leukemia. More specifically, the invention relates to isolated nucleic acid of the human SH3D1A gene, products, and their use in diagnosis and treatments. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the SH3D1A gene for mutations, which are useful for diagnosing the predisposition to hematopoietic disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.