Butyrylcholinesterase variants and methods of use
US7070973B2 · kind B2 · utility
1Cited by
3References
2Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Dec 26, 2000 |
| Grant date | Jul 4, 2006 |
| Priority date | — |
| Expiry date | Aug 13, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides four butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention also provides libraries comprising butyrylcholinesterase variants having at least one amino acid alteration in one or more regions of butyrylcholinesterase and further having at least one butyrylcholinesterase variant exhibiting enhanced cocaine hydrolysis activity compared to butyrylcholinesterase. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.