Combined use of cementum attachment protein and cyclosporin a for improved attachment of dental and orthopedic implants
US7071162B1 · kind B1 · utility
Inventors
Key dates
| Filing date | Apr 9, 2003 |
| Grant date | Jul 4, 2006 |
| Priority date | — |
| Expiry date | Sep 22, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P19/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is described for inducing the formation of cementum and a periodontal ligament between a dental implant and bone by administering cementum attachment protein (CAP) together with a calcineurin inhibitor such as cyclosporin A (CSA). Also contemplated is an implant kit comprising a titanium or other biologically inert dental or orthopedic implant and a coating of CAP and a calcineurin inhibitor such as CSA. Furthermore, application of CAP and CSA to dental root surfaces can be used to induce the regeneration of a periodontal ligament during treatment for periodontal disease. A similar method for reattaching a fibrous structure, such as a tendon, ligament or joint capsule, to bone is described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.