Peptide and polypeptide inhibitors of complement C1s
US7071299B2 · kind B2 · utility
23Cited by
0References
3Claims
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Assignee
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Key dates
| Filing date | Jun 18, 2001 |
| Grant date | Jul 4, 2006 |
| Priority date | — |
| Expiry date | Sep 19, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The complement system plays an important role in providing resistance to infections and in the pathogenesis of tissue injury. Yet an inappropriate activation of complement can result in a variety of disorders. The present invention provides C1s catalytic site-directed moieties, C1s exosite binding moieties, and bivalent polypeptide inhibitors comprising such moieties, which can be used to treat conditions characterized by inappropriate complement activation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.