Synthesis of 2-hydroxy-N,N-dimethyl-3-[ [2-[1 (R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]aminobenzamide

US7071342B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Jianguo Yin · Plainsboro, US
• Xiaoyong Fu · Edison, US
• Shuyi Zhang · Parsippany, US
• Timothy L. McAllister · Westfield, US
• Agnes S. Kim-Meade · Fanwood, US
• Jason L. Winters · Plainsboro, US
• Anantha Sudhakar · East Brunswick Township, US
• Doris P. Schumacher · Florham Park, US

Key dates

• Filing date: Apr 16, 2004
• Grant date: Jul 4, 2006
• Expiry date: Apr 16, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C235/60
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a process for making the compound of formula I:using the compounds of formulas II, Q, and XI or XII:wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1–C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.