Retroviral vectors carrying senescent cell derived inhibitors 1 (SDI-1)or antisense SDI-1 nucleotide sequences
US7074398B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 10, 1998 |
| Grant date | Jul 11, 2006 |
| Priority date | — |
| Expiry date | Apr 10, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/12043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to retroviral vectors carrying DNA sequences encoding SDI-1, function analogues of SDI-1, or fragments thereof, or antisense SDI-1 DNA sequences, and especially retroviral vectors carrying the SDI-1 or antisense SDI-1 sequences under the transcriptional control of target cell specific regulatory elements or promoters or X-ray inducible promoters. Further, the invention relates to the use of such retroviral vectors for the production of recombinant retroviral particles useful for the treatment of disorders or diseases responsive to the anti-proliferative activity of SDI-1, or the proliferative activity of antisense SDI-1 sequences.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.