Isothermal amplification based assay for the detection and quantitation of alpha-fetoprotein mRNA
US7074561B2 · kind B2 · utility
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5References
19Claims
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Key dates
| Filing date | Oct 22, 2002 |
| Grant date | Jul 11, 2006 |
| Priority date | — |
| Expiry date | Aug 3, 2024 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/81
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is directed to isothermal transcription based assays for the detection and quantification of alpha-fetoprotein (AFP) mRNA. The present invention is also directed to oligonucleotides for amplifying AFP mRNA and probes for use in the detection and quantification of the amplification product. The present invention is also directed to detecting hepatocellular carcinoma, metastasis thereof and tumor recurrence by analyzing peripheral blood for the presence of AFP mRNA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.