Patent · US Expired

Controlling protein levels in eucaryotic organisms

US7074620B2 · kind B2 · utility

50Cited by
3References
24Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJun 14, 2001
Grant dateJul 11, 2006
Priority date—
Expiry dateJun 14, 2021

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY02A50/30
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Method for reducing the level and/or activity of a target protein in a eukaryotic cell via activation of ubiquitination of the target protein wherein the cell is contacted with the compound having a ubiquitination recognition element covalently linked to a target protein binding element. The ubiquitination and recognition element can bind to either the E3 or E2 elements of the ubiquitination system and the target protein binding element is able to bind specifically to the target protein. The target protein binding element has a molecular weight of less than 30,000 and has a binding affinity for the target protein greater than 105M31 1.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.