Amidino derivatives and their use as thrombin inhibitors

US7074820B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventor

• Thomas Antonsson · Lindome, SE

Key dates

• Filing date: Apr 23, 2001
• Grant date: Jul 11, 2006
• Expiry date: Sep 10, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/5304
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There is provided compounds of formula I,wherein R1, R2, R3, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.