Method for purifying 5′ -protected 2′ -deoxypurine nucleosides
US7074917B2 · kind B2 · utility
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Key dates
| Filing date | Aug 16, 2005 |
| Grant date | Jul 11, 2006 |
| Priority date | — |
| Expiry date | Aug 20, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H1/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for efficiently purifying 5′ protected 2′-deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5′ protected 2′-deoxypurine nucleoside as an inclusion crystal including a solvent such as that having a nitrile structure in order to purify the 5′ protected 2′-deoxypurine nucleoside at a high purity. This invention enables synthesis of highly purified, protected deoxypurine nucleosides easily on a large scale, which has previously been performed by column chromatography method.
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