Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
US7074983B2 · kind B2 · utility
20Cited by
98References
19Claims
0Family size
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Key dates
| Filing date | Nov 16, 2001 |
| Grant date | Jul 11, 2006 |
| Priority date | — |
| Expiry date | Jan 23, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/30
- WIPO fieldOther special machines
- WIPO sectorMechanical engineering
Abstract
The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of non-bovine antibodies, preferably human antibodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.