Methods for the identification of inhibitors of an isoprenoid metabolic pathway
US7078169B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 26, 2002 |
| Grant date | Jul 18, 2006 |
| Priority date | — |
| Expiry date | Jul 18, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B30/10
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
The present invention relates to methods of identifying genes whose expression is indicative of activation of a particular biochemical or metabolic pathway or a common set of biological reactions or functions in a cell (“regulon indicator genes”) The present invention provides an example of such an indicator gene. The present invention also relates to methods of partially characterizing a gene of unknown function by determining which biological pathways, reactions or functions its expression is associated with, thereby placing the gene within a functional genetic group or “regulon”. These partially characterized genes may be used to identify desirable therapeutic targets of biological pathways of interest (“regulon target genes”) The present invention provides examples of such target genes. Methods for identifying effectors (activators and inhibitors) of regulon target genes are provided. The present invention also provides examples of regulon target gene inhibitors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.