Antibacterial agents comprising conjugates of glycopeptides and peptidic membrane associating elements
US7078380B2 · kind B2 · utility
6Cited by
2References
12Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Nov 2, 2001 |
| Grant date | Jul 18, 2006 |
| Priority date | — |
| Expiry date | Nov 2, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns agents with anti-bacterial activity and methods and intermediates for their production. The present invention further concerns the use of such agents for the treatment of bacterial infections in animals, including man. The agents are derivatives of vancomycin-type antibiotics, of structure: V-L-W-X; wherein V is a glycopeptide moiety which inhibits peptidoglycan biosynthesis in bacteria; L is a linking group; W is a peptidic membrane-associating element such as an element based on naturally-occurring animal or bacterial peptide antibiotics; and X is hydrogen or a membrane-insertive element.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.