Process for the synthesis of ganciclovir

US7078524B2 · kind B2 · utility

Assignee

• RANBAXY LABORATORIES LIMITED · IN

Inventors

• Jayachandra Babu · Barwala, IN
• Purna Chandra Ray · Pune, IN
• Yatendra Kumar · Barwala, IN
• Chandra Has Khanduri · Manesar, IN

Key dates

• Filing date: Nov 22, 2002
• Grant date: Jul 18, 2006
• Expiry date: Jul 6, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to an industrial useful process for the synthesis of antiviral compound, ganciclovir which comprises dissolving a mixture containing N-7 and N-9 isomers of structural formulae, II and III, respectively: in a solvent or a mixture of solvents; separating the N-7 and N-9 isomers; and hydrolizing the N-9 isomer to obtain ganciclovir.