Benzimidazole vascular damaging agents
US7081469B2 · kind B2 · utility
1Cited by
5References
14Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jul 3, 2003 |
| Grant date | Jul 25, 2006 |
| Priority date | — |
| Expiry date | Jan 14, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D235/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Vascular damaging agents composed of substituted 5(6)-substituted benzimidazole-2-carbamates are provided. These agents are useful in the preparation of medicaments for the treatment of diseases involving neovascularisation, particularly for the treatment of solid tumors, macular degeneration, diabetic retinopathy, rheumatoid arthritis, psoriasis, and atherosclerosis. Embodiments include a 5(6)-substituted benzimidazole-2-carbamate of formula Iwherein A represents a multi-substituted alkyl group or aromatic ring.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.