Recombinant vaccine against botulinum neurotoxin

US7081529B2 · kind B2 · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• Leonard A. Smith · Clarksburg, US
• Michael Byrne · New Market, US
• John L. Middlebrook · Middletown, US
• Hugh Lapenotiere · Martinsburg, US
• Michael A. Clayton · Mount Airy, US
• Douglas R. Brown · Gaithersburg, US

Key dates

• Filing date: Jul 20, 2001
• Grant date: Jul 25, 2006
• Expiry date: Jul 20, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention is directed to preparation and expression of synthetic genes encoding polypeptides containing protective epitopes of botulinum neurotoxin (BoNT). The invention is also directed to production of immunogenic peptides encoded by the synthetic genes, as weel as recovery and purification of the immunogenic peptides from recombinant organisms. The invention is also directed to methods of vaccination against botulism using the expressed peptides.