Gene-targeted animal model of apolipoprotein E4 domain interaction and uses thereof
US7081561B2 · kind B2 · utility
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6Claims
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Key dates
| Filing date | Dec 14, 2001 |
| Grant date | Jul 25, 2006 |
| Priority date | — |
| Expiry date | Dec 14, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/044
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides gene-targeted non-human animals comprising a genetically modified apoE gene encodes a recombinant apoE polypeptide displaying domain interaction. The invention further provides cells isolated from the gene-targeted animals, which cells produce a recombinant apoE polypeptide displaying domain interaction. The invention further provides methods of identifying agents that reduce apoE4 domain interaction, and which are useful to treat apoE4-related neurological and cardiovascular disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.