Methods
US7083511B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 14, 1999 |
| Grant date | Aug 1, 2006 |
| Priority date | — |
| Expiry date | Dec 14, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/485
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method of activating serum and glucocorticoid-induced protein kinase (SGK) is provided wherein the SGK is phosphorylated. The SGK may be phosphorylated by PDK1 and/or a preparation containing PDK2 activity. A method of identifying a compound that modulates the activity of SGK is provided, wherein the activity of SGK is measured by measuring the phosphorylation by SGK of a polypeptide comprising an amino acid sequence corresponding to the consensus sequence (Arg/Lys; preferably Arg)-X-(X/Arg)-X-X-Ser/Thr)-Z wherein X indicates any amino acid, X/Arg indicates any amino acid, with a preference for arginine, and Z indicates that the amino acid residue is preferably a hydrophobic residue. The SGK may be activated by phosphorylation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.