Stereoselective reduction of substituted oxo-butanes
US7083973B2 · kind B2 · utility
12Cited by
2References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 12, 2003 |
| Grant date | Aug 1, 2006 |
| Priority date | — |
| Expiry date | Jan 17, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P13/001
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a process for the stereoselective enzymatic reduction of 1-halo-2-oxo-3-(protected)amino-4-substituted-butanes utilizing certain species of Rhodococcus and Brevibacterium. The product 1-halo-2-hydroxy-3-(protected)amino-4-substituted-butanes, which are useful as intermediates in the synthesis of compounds that are inhibitors of ACE, renin and HIV proteases, are obtained in high yield and, particularly, in very high diastereomeric purity. The process is advantageously highly selective for the (3S,2R) enantiomer of the product.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.