Therapeutic agents and methods of use thereof for the modulation of angiogenesis
US7084108B2 · kind B2 · utility
54Cited by
13References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 1, 2001 |
| Grant date | Aug 1, 2006 |
| Priority date | — |
| Expiry date | May 10, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/8146
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an angiogenic disease, e.g., cancer, in a subject by administering to the subject a therapeutically effective amount of one or more of the angiogenesis inhibitor compounds of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.