Artemisinins with improved stability and bioavailability for therapeutic drug development and application
US7084132B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Apr 25, 2005 |
| Grant date | Aug 1, 2006 |
| Priority date | — |
| Expiry date | Apr 25, 2025 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A stable form of artemisinin wherein an artelinic acid or artesunic acid is complexed with cyclodextrin analogs, preferably, β-cyclodextrin. The complexed cyclodextrin artemisinin formulation shields the peroxide portion of the artemisinin backbone from hydrolytic decomposition rendering it stable in solution. Artelinic acid and cyclodextrin are placed into contact with one another to yield a 2:1 molecular species. Artesunic acid and cyclodextrin yield a 1:1 molecular species. The complexed cyclodextrin artemisinin formulation is effective for the treatment of malaria and is stable in solution for long periods of time.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.