Peptide composition and method for delivering substances into the cytosol of cells
US7084248B2 · kind B2 · utility
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26Claims
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Key dates
| Filing date | Sep 20, 2004 |
| Grant date | Aug 1, 2006 |
| Priority date | — |
| Expiry date | Sep 20, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/6072
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Weak-base amphiphilic delivery peptide compositions are described for use in delivering large polar substances (cargo) into the cytosol of animal cells via an indirect endocytosis-mediated delivery process. The delivery peptides, which are predominantly non-ionic at neutral pH, bind but do not permeabilize cell membranes. After endocytosis of both delivery peptides and cargo, acidification of the endosome converts the delivery peptides to their polycationic form, whereupon they permeabilize the endosomal membrane and allow co-endocytosed cargo to pass from the endosome to the cytosol of the cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.