DB, the receptor for leptin
US7084252B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 16, 1996 |
| Grant date | Aug 1, 2006 |
| Priority date | — |
| Expiry date | Jan 16, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/72
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.