β-secretase and modulation of β-secretase activity
US7087399B1 · kind B1 · utility
3Cited by
2References
36Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 9, 2000 |
| Grant date | Aug 8, 2006 |
| Priority date | — |
| Expiry date | May 9, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns a novel β-secretase, a method of partially purifying this novel β-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and other neurological diseases. The novel β-secretase has an estimated molecular weight of about 32-39 kDa or 22-26 kDa in HEK293 cell membrane extracts and human brain samples, respectively, as calculated from radiation inactivation analysis, and has a pH optimum at about pH 6.5-7.0.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.