Membrane countercurrent exchanger and membrane inlet mass spectrometer for the analysis of gas partial pressure in liquid samples
US7087436B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 20, 2003 |
| Grant date | Aug 8, 2006 |
| Priority date | — |
| Expiry date | Jun 20, 2023 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/25875
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method and apparatus for the analysis of blood or other liquids by mass spectrometry to determine the partial pressures of gases and other volatile substances dissolved in the blood or other liquid in a manner independent of the solubility of the gases in the blood or other liquid. A countercurrent membrane exchanger (CCME) is provided for equilibrating a carrier fluid with the sample of blood or other liquid, the output of which is coupled to a tubular direct insertion membrane probe (t-DIMP) type of membrane inlet mass spectrometer. The CCME preferably has complementary spiral grooves on opposing metal plates for the water carrier and sample liquids so as to induce secondary flows which greatly reduce the resistance to equilibration between the liquid sample and water carrier phases. The t-DIMP is characterized by the use of Teflon™ sleeves specifically to reduce noise introduced at the connection between the silicone membrane in the t-DIMP and the steel tubing for the water carrier, by the use of radiation shields to prevent heating of the silicone membrane and water carrier to allow lower carrier flow rates, and by the heating of the section between the ion source and the vac…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.