Compositions comprising purified 2-methoxyestradiol and methods of producing same
US7087592B1 · kind B1 · utility
9Cited by
61References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 23, 2000 |
| Grant date | Aug 8, 2006 |
| Priority date | — |
| Expiry date | Mar 12, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J1/007
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
2-methoxyestradiol having greater than 98% purity is obtained by synthetic or purification methods. This highly pure 2-methoxy estradiol, lacking estrogenic components, is particularly suitable for clinical use in humans. The purification methods of the invention involve the use of liquid-solid chromatography (LSC) to separate 2-ME2 from other compounds. The chromatographic media is preferably silica. The solvent system comprises a non-polar solvent, such as chloroform, and a polar solvent, such as methanol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.