Methods for modulating macrophage proliferation using polyamine analogs
US7087648B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Oct 26, 1998 |
| Grant date | Aug 8, 2006 |
| Priority date | — |
| Expiry date | Oct 26, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2821
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for modulating macrophage proliferation in an individual afflicted with or at risk for a macrophage-associated disease are provided. The methods employ a polyamine analog, or salt or protected derivative thereof. Macrophage proliferation has been implicated in a number of serious disorders, including AIDS (HIV)-associated dementia, AIDS-associated non-Hodgkin's lymphoma, and Alzheimer's disease. The invention also provides methods for aiding diagnosis and monitoring therapy of a macrophage-associated non-HIV associated dementia, especially Alzheimer's disease. The invention also provides methods of delaying development of macrophage-associated non-HIV associated dementias, including Alzheimer's disease, which entail administration of an agent which modulates macrophage proliferation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.