Hepatitis C inhibitor tri-peptides

US7091184B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Montse Llinas-Brunet · Dollard-Des-Ormeaux, CA
• Murray D. Bailey · Laval, CA
• Elise Ghiro · Laval, CA

Key dates

• Filing date: Jan 29, 2003
• Grant date: Aug 15, 2006
• Expiry date: Oct 30, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I):wherein R1 is hydroxyl or sulfonamide derivative; R2 is t-butyl or —CH2—C(CH3)3 or —CH2-cyclopentyl; R3 is t-butyl or cyclohexyl and R4 is cyclobutyl, cyclopentyl or cyclohexyl; or a pharmaceutically acceptable salt thereof, are described as useful as inhibitor of the HCV NS3 protease.