Dihydroxypyridmidine carboxylic acids as viral polymerase inhibitors

US7091209B2 · kind B2 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Cristina Gardelli · Pomezia, IT
• Claudio Giuliano · Como, IT
• Steven Harper · Roma, IT
• Uwe Koch · Roma, IT
• Frank Narjes · Ariccia, IT
• Jesus Maria Ontoria Ontoria · Pomezia, IT
• Marco Poma · Grosseto, IT
• Simona Ponzi · Pomezia, IT
• Ian Stansfield · Roma, IT
• Vincenzo Summa · Pomezia, IT

Key dates

• Filing date: Jul 11, 2001
• Grant date: Aug 15, 2006
• Expiry date: Jun 10, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A class of 2-aryl-4,5-dihydroxy-6-carboxypyrimidines of formula (I): wherein Ar is an optionally substituted aryl or heterocyclicgroup; as well as compounds of formula (I) which are derivatized at one or more of the 4-hydroxy, 5-hydroxy or 6-carboxy groups; and tautomers thereof, and pharmaceutically acceptable salts or esters thereof; and inhibitors of viral polymerases, especially the hepatitis C virus (HCV) polymerase enzyme